Nox4 as a potential therapeutic target for treatment of uremic toxicity associated to chronic kidney disease

Watanabe et al. report that Nox4 NADPH oxidase catalytic moiety and the subunit p22(phox) mediate the increase in oxidative stress and human tubular epithelial cell injury induced by p-cresyl sulfate, a protein-bound uremic toxin. These findings could be instrumental for the design of novel therapeu...

Descripción completa

Detalles Bibliográficos
Autor principal: Gorin, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616333/
https://www.ncbi.nlm.nih.gov/pubmed/23538692
http://dx.doi.org/10.1038/ki.2012.434
_version_ 1782265139865583616
author Gorin, Yves
author_facet Gorin, Yves
author_sort Gorin, Yves
collection PubMed
description Watanabe et al. report that Nox4 NADPH oxidase catalytic moiety and the subunit p22(phox) mediate the increase in oxidative stress and human tubular epithelial cell injury induced by p-cresyl sulfate, a protein-bound uremic toxin. These findings could be instrumental for the design of novel therapeutic intervention utilizing small molecule inhibitors specifically targeting Nox oxidases to prevent or slow down the progression of chronic kidney disease and the associated disorders due to uremic toxicity.
format Online
Article
Text
id pubmed-3616333
institution National Center for Biotechnology Information
language English
publishDate 2013
record_format MEDLINE/PubMed
spelling pubmed-36163332013-10-01 Nox4 as a potential therapeutic target for treatment of uremic toxicity associated to chronic kidney disease Gorin, Yves Kidney Int Article Watanabe et al. report that Nox4 NADPH oxidase catalytic moiety and the subunit p22(phox) mediate the increase in oxidative stress and human tubular epithelial cell injury induced by p-cresyl sulfate, a protein-bound uremic toxin. These findings could be instrumental for the design of novel therapeutic intervention utilizing small molecule inhibitors specifically targeting Nox oxidases to prevent or slow down the progression of chronic kidney disease and the associated disorders due to uremic toxicity. 2013-04 /pmc/articles/PMC3616333/ /pubmed/23538692 http://dx.doi.org/10.1038/ki.2012.434 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Gorin, Yves
Nox4 as a potential therapeutic target for treatment of uremic toxicity associated to chronic kidney disease
title Nox4 as a potential therapeutic target for treatment of uremic toxicity associated to chronic kidney disease
title_full Nox4 as a potential therapeutic target for treatment of uremic toxicity associated to chronic kidney disease
title_fullStr Nox4 as a potential therapeutic target for treatment of uremic toxicity associated to chronic kidney disease
title_full_unstemmed Nox4 as a potential therapeutic target for treatment of uremic toxicity associated to chronic kidney disease
title_short Nox4 as a potential therapeutic target for treatment of uremic toxicity associated to chronic kidney disease
title_sort nox4 as a potential therapeutic target for treatment of uremic toxicity associated to chronic kidney disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616333/
https://www.ncbi.nlm.nih.gov/pubmed/23538692
http://dx.doi.org/10.1038/ki.2012.434
work_keys_str_mv AT gorinyves nox4asapotentialtherapeutictargetfortreatmentofuremictoxicityassociatedtochronickidneydisease

Ejemplares similares