The anti-genomic (negative) strand of Hepatitis C Virus is not targetable by shRNA

Hepatitis C Virus (HCV) and other plus-strand RNA viruses typically require the generation of a small number of negative genomes (20–100× lower than the positive genomes) for replication, making the less-abundant antigenome an attractive target for RNA interference(RNAi)-based therapy. Because of th...

Descripción completa

Detalles Bibliográficos
Autores principales: Lisowski, Leszek, Elazar, Menashe, Chu, Kirk, Glenn, Jeffrey S., Kay, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616702/
https://www.ncbi.nlm.nih.gov/pubmed/23396439
http://dx.doi.org/10.1093/nar/gkt068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616702/
https://www.ncbi.nlm.nih.gov/pubmed/23396439
http://dx.doi.org/10.1093/nar/gkt068

Ejemplares similares