A comprehensive approach to zinc-finger recombinase customization enables genomic targeting in human cells

Zinc-finger recombinases (ZFRs) represent a potentially powerful class of tools for targeted genetic engineering. These chimeric enzymes are composed of an activated catalytic domain derived from the resolvase/invertase family of serine recombinases and a custom-designed zinc-finger DNA-binding doma...

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Detalles Bibliográficos
Autores principales: Gaj, Thomas, Mercer, Andrew C., Sirk, Shannon J., Smith, Heather L., Barbas, Carlos F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Synthetic Biology and Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616721/
https://www.ncbi.nlm.nih.gov/pubmed/23393187
http://dx.doi.org/10.1093/nar/gkt071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616721/
https://www.ncbi.nlm.nih.gov/pubmed/23393187
http://dx.doi.org/10.1093/nar/gkt071

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