U2AF(65) adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs

Degenerate splice site sequences mark the intron boundaries of pre-mRNA transcripts in multicellular eukaryotes. The essential pre-mRNA splicing factor U2AF(65) is faced with the paradoxical tasks of accurately targeting polypyrimidine (Py) tracts preceding 3′ splice sites while adapting to both cyt...

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Detalles Bibliográficos
Autores principales: Jenkins, Jermaine L., Agrawal, Anant A., Gupta, Ankit, Green, Michael R., Kielkopf, Clara L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616741/
https://www.ncbi.nlm.nih.gov/pubmed/23376934
http://dx.doi.org/10.1093/nar/gkt046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616741/
https://www.ncbi.nlm.nih.gov/pubmed/23376934
http://dx.doi.org/10.1093/nar/gkt046

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