U2AF(65) adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs

Degenerate splice site sequences mark the intron boundaries of pre-mRNA transcripts in multicellular eukaryotes. The essential pre-mRNA splicing factor U2AF(65) is faced with the paradoxical tasks of accurately targeting polypyrimidine (Py) tracts preceding 3′ splice sites while adapting to both cyt...

Descripción completa

Detalles Bibliográficos
Autores principales: Jenkins, Jermaine L., Agrawal, Anant A., Gupta, Ankit, Green, Michael R., Kielkopf, Clara L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616741/
https://www.ncbi.nlm.nih.gov/pubmed/23376934
http://dx.doi.org/10.1093/nar/gkt046

Ejemplares similares

Ejemplares similares