16/6-idiotype expressing antibodies induce brain inflammation and cognitive impairment in mice: the mosaic of central nervous system involvement in lupus

BACKGROUND: The 16/6-idiotype (16/6-Id) of the human anti-DNA antibody was found to induce experimental lupus in naïve mice, manifested by production of autoantibodies, leukopenia and elevated inflammatory markers, as well as kidney and brain involvement. We assessed behavior and brain pathology of...

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Detalles Bibliográficos
Autores principales: Kivity, Shaye, Katzav, Aviva, Arango, Maria Teresa, Landau-Rabi, Moran, Zafrir, Yaron, Agmon-Levin, Nancy, Blank, Miri, Anaya, Juan-Manuel, Mozes, Edna, Chapman, Joab, Shoenfeld, Yehuda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616817/
https://www.ncbi.nlm.nih.gov/pubmed/23556432
http://dx.doi.org/10.1186/1741-7015-11-90

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616817/
https://www.ncbi.nlm.nih.gov/pubmed/23556432
http://dx.doi.org/10.1186/1741-7015-11-90

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