Identification of Rtl1, a Retrotransposon-Derived Imprinted Gene, as a Novel Driver of Hepatocarcinogenesis

We previously utilized a Sleeping Beauty (SB) transposon mutagenesis screen to discover novel drivers of HCC. This approach identified recurrent mutations within the Dlk1-Dio3 imprinted domain, indicating that alteration of one or more elements within the domain provides a selective advantage to cel...

Descripción completa

Detalles Bibliográficos
Autores principales: Riordan, Jesse D., Keng, Vincent W., Tschida, Barbara R., Scheetz, Todd E., Bell, Jason B., Podetz-Pedersen, Kelly M., Moser, Catherine D., Copeland, Neal G., Jenkins, Nancy A., Roberts, Lewis R., Largaespada, David A., Dupuy, Adam J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616914/
https://www.ncbi.nlm.nih.gov/pubmed/23593033
http://dx.doi.org/10.1371/journal.pgen.1003441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616914/
https://www.ncbi.nlm.nih.gov/pubmed/23593033
http://dx.doi.org/10.1371/journal.pgen.1003441

Ejemplares similares