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Identification of Rtl1, a Retrotransposon-Derived Imprinted Gene, as a Novel Driver of Hepatocarcinogenesis

We previously utilized a Sleeping Beauty (SB) transposon mutagenesis screen to discover novel drivers of HCC. This approach identified recurrent mutations within the Dlk1-Dio3 imprinted domain, indicating that alteration of one or more elements within the domain provides a selective advantage to cel...

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Detalles Bibliográficos
Autores principales:	Riordan, Jesse D., Keng, Vincent W., Tschida, Barbara R., Scheetz, Todd E., Bell, Jason B., Podetz-Pedersen, Kelly M., Moser, Catherine D., Copeland, Neal G., Jenkins, Nancy A., Roberts, Lewis R., Largaespada, David A., Dupuy, Adam J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616914/ https://www.ncbi.nlm.nih.gov/pubmed/23593033 http://dx.doi.org/10.1371/journal.pgen.1003441

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