Data-Driven Modeling of Src Control on the Mitochondrial Pathway of Apoptosis: Implication for Anticancer Therapy Optimization

Src tyrosine kinases are deregulated in numerous cancers and may favor tumorigenesis and tumor progression. We previously described that Src activation in NIH-3T3 mouse fibroblasts promoted cell resistance to apoptosis. Indeed, Src was found to accelerate the degradation of the pro-apoptotic BH3-onl...

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Detalles Bibliográficos
Autores principales: Ballesta, Annabelle, Lopez, Jonathan, Popgeorgiev, Nikolay, Gonzalo, Philippe, Doumic, Marie, Gillet, Germain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616992/
https://www.ncbi.nlm.nih.gov/pubmed/23592961
http://dx.doi.org/10.1371/journal.pcbi.1003011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616992/
https://www.ncbi.nlm.nih.gov/pubmed/23592961
http://dx.doi.org/10.1371/journal.pcbi.1003011

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