A Two-State Model for the Dynamics of the Pyrophosphate Ion Release in Bacterial RNA Polymerase

The dynamics of the PP(i) release during the transcription elongation of bacterial RNA polymerase and its effects on the Trigger Loop (TL) opening motion are still elusive. Here, we built a Markov State Model (MSM) from extensive all-atom molecular dynamics (MD) simulations to investigate the mechan...

Descripción completa

Detalles Bibliográficos
Autores principales: Da, Lin-Tai, Pardo Avila, Fátima, Wang, Dong, Huang, Xuhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617016/
https://www.ncbi.nlm.nih.gov/pubmed/23592966
http://dx.doi.org/10.1371/journal.pcbi.1003020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617016/
https://www.ncbi.nlm.nih.gov/pubmed/23592966
http://dx.doi.org/10.1371/journal.pcbi.1003020

Ejemplares similares