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A Two-State Model for the Dynamics of the Pyrophosphate Ion Release in Bacterial RNA Polymerase
The dynamics of the PP(i) release during the transcription elongation of bacterial RNA polymerase and its effects on the Trigger Loop (TL) opening motion are still elusive. Here, we built a Markov State Model (MSM) from extensive all-atom molecular dynamics (MD) simulations to investigate the mechan...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617016/ https://www.ncbi.nlm.nih.gov/pubmed/23592966 http://dx.doi.org/10.1371/journal.pcbi.1003020 |