Pharmacometabolomic Approach to Predict QT Prolongation in Guinea Pigs

Drug-induced torsades de pointes (TdP), a life-threatening arrhythmia associated with prolongation of the QT interval, has been a significant reason for withdrawal of several medicines from the market. Prolongation of the QT interval is considered as the best biomarker for predicting the torsadogeni...

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Detalles Bibliográficos
Autores principales: Park, Jeonghyeon, Noh, Keumhan, Lee, Hae Won, Lim, Mi-sun, Seong, Sook Jin, Seo, Jeong Ju, Kim, Eun-Jung, Kang, Wonku, Yoon, Young-Ran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617128/
https://www.ncbi.nlm.nih.gov/pubmed/23593245
http://dx.doi.org/10.1371/journal.pone.0060556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617128/
https://www.ncbi.nlm.nih.gov/pubmed/23593245
http://dx.doi.org/10.1371/journal.pone.0060556

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