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β5i Subunit Deficiency of the Immunoproteasome Leads to Reduced Th2 Response in OVA Induced Acute Asthma

The immunoproteasome subunit β5i has been shown to play an important role in Th1/Th17 driven models of colitis and arthritis. However, the function of β5i in Th2 dependent diseases remains enigmatic. To study the role of β5i in Th2-driven pathology, β5i knockout (KO) and control mice were tested in...

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Detalles Bibliográficos
Autores principales: Volkov, Anton, Hagner, Stefanie, Löser, Stephan, Alnahas, Safa, Raifer, Hartmann, Hellhund, Anne, Garn, Holger, Steinhoff, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617144/
https://www.ncbi.nlm.nih.gov/pubmed/23593249
http://dx.doi.org/10.1371/journal.pone.0060565