ERCC1 and ERCC2 Haplotype Modulates Induced BPDE-DNA Adducts in Primary Cultured Lymphocytes

BACKGROUND: Benzo[a]pyrene(B[a]P), and its ultimate metabolite Benzo[a]pyrene 7,8-diol 9,10-epoxide (BPDE), are classic DNA damaging carcinogens. DNA damage caused by BPDE is normally repaired by Nucleotide Excision Repair (NER), of which ERCC1 and ERCC2/XPD exert an indispensable role. Genetic vari...

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Detalles Bibliográficos
Autores principales: Lu, Xiaobo, Liu, Yanhua, Yu, Tao, Xiao, Sha, Bao, Xiaoyan, Pan, Liang, Zhu, Guolian, Cai, Yuan, Liu, Qiufang, Jin, Cuihong, Yang, Jinghua, Wu, Shengwen, An, Li, van der Straaten, Tahar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617188/
https://www.ncbi.nlm.nih.gov/pubmed/23593158
http://dx.doi.org/10.1371/journal.pone.0060006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617188/
https://www.ncbi.nlm.nih.gov/pubmed/23593158
http://dx.doi.org/10.1371/journal.pone.0060006

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