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ERCC1 and ERCC2 Haplotype Modulates Induced BPDE-DNA Adducts in Primary Cultured Lymphocytes
BACKGROUND: Benzo[a]pyrene(B[a]P), and its ultimate metabolite Benzo[a]pyrene 7,8-diol 9,10-epoxide (BPDE), are classic DNA damaging carcinogens. DNA damage caused by BPDE is normally repaired by Nucleotide Excision Repair (NER), of which ERCC1 and ERCC2/XPD exert an indispensable role. Genetic vari...
Autores principales: | Lu, Xiaobo, Liu, Yanhua, Yu, Tao, Xiao, Sha, Bao, Xiaoyan, Pan, Liang, Zhu, Guolian, Cai, Yuan, Liu, Qiufang, Jin, Cuihong, Yang, Jinghua, Wu, Shengwen, An, Li, van der Straaten, Tahar |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617188/ https://www.ncbi.nlm.nih.gov/pubmed/23593158 http://dx.doi.org/10.1371/journal.pone.0060006 |
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