Synthetic Lethality between Gene Defects Affecting a Single Non-essential Molecular Pathway with Reversible Steps

Systematic analysis of synthetic lethality (SL) constitutes a critical tool for systems biology to decipher molecular pathways. The most accepted mechanistic explanation of SL is that the two genes function in parallel, mutually compensatory pathways, known as between-pathway SL. However, recent gen...

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Detalles Bibliográficos
Autores principales: Zinovyev, Andrei, Kuperstein, Inna, Barillot, Emmanuel, Heyer, Wolf-Dietrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617211/
https://www.ncbi.nlm.nih.gov/pubmed/23592964
http://dx.doi.org/10.1371/journal.pcbi.1003016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617211/
https://www.ncbi.nlm.nih.gov/pubmed/23592964
http://dx.doi.org/10.1371/journal.pcbi.1003016

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