Genetic Diversity in Normal Cell Populations is the Earliest Stage of Oncogenesis Leading to Intra-Tumor Heterogeneity

Random mutations and epigenetic alterations provide a rich substrate for microevolutionary phenomena to occur in proliferating epithelial tissues. Genetic diversity resulting from random mutations in normal cells is critically important for understanding the genetic basis of oncogenesis. However, ev...

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Detalles Bibliográficos
Autores principales: Howk, Cory L., Voller, Zachary, Beck, Brandon B., Dai, Donghai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617357/
https://www.ncbi.nlm.nih.gov/pubmed/23577323
http://dx.doi.org/10.3389/fonc.2013.00061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617357/
https://www.ncbi.nlm.nih.gov/pubmed/23577323
http://dx.doi.org/10.3389/fonc.2013.00061

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