Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency

The gene encoding the Krebs cycle enzyme fumarate hydratase (FH) is mutated in hereditary leiomyomatosis and renal cell cancer (HLRCC). Loss of FH activity causes accumulation of intracellular fumarate, which can directly modify cysteine residues to form 2-succinocysteine through succination. We und...

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Detalles Bibliográficos
Autores principales: Ternette, Nicola, Yang, Ming, Laroyia, Mahima, Kitagawa, Mitsuhiro, O’Flaherty, Linda, Wolhulter, Kathryn, Igarashi, Kaori, Saito, Kaori, Kato, Keiko, Fischer, Roman, Berquand, Alexandre, Kessler, Benedikt M., Lappin, Terry, Frizzell, Norma, Soga, Tomoyoshi, Adam, Julie, Pollard, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617368/
https://www.ncbi.nlm.nih.gov/pubmed/23499446
http://dx.doi.org/10.1016/j.celrep.2013.02.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617368/
https://www.ncbi.nlm.nih.gov/pubmed/23499446
http://dx.doi.org/10.1016/j.celrep.2013.02.013

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