Cyclooxygenase-2 dependent metabolism of 20-HETE increases adiposity and adipocyte enlargement in mesenchymal stem cell-derived adipocytes

20-Hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE), a product of the cytochrome P450 (CYP)-catalyzed ω-hydroxylation of arachidonic acid, induces oxidative stress and, in clinical studies, is associated with increased body mass index (BMI) and the metabolic syndrome. This study was designed to exa...

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Detalles Bibliográficos
Autores principales: Kim, Dong Hyun, Puri, Nitin, Sodhi, Komal, Falck, John R., Abraham, Nader G., Shapiro, Joseph, Schwartzman, Michal L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617952/
https://www.ncbi.nlm.nih.gov/pubmed/23293373
http://dx.doi.org/10.1194/jlr.M033894

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617952/
https://www.ncbi.nlm.nih.gov/pubmed/23293373
http://dx.doi.org/10.1194/jlr.M033894

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