Cargando…

Enzyme inhibition of dopamine metabolism alters 6-[(18)F]FDOPA uptake in orthotopic pancreatic adenocarcinoma

BACKGROUND: An unknown location hampers removal of pancreatic tumours. We studied the effects of enzyme inhibitors on the uptake of 6-[(18)F]fluoro-l-3,4-dihydroxyphenylalanine ([(18)F]FDOPA) in the pancreas, aiming at improved imaging of pancreatic adenocarcinoma. METHODS: Mice bearing orthotopic B...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tuomela, Johanna, Forsback, Sarita, Haavisto, Laura, Vahlberg, Tero, Grönroos, Tove J, Solin, Olof, Haaparanta-Solin, Merja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618317/ https://www.ncbi.nlm.nih.gov/pubmed/23497589 http://dx.doi.org/10.1186/2191-219X-3-18

Ejemplares similares

[(18)F]Fluoride uptake in various bone types and soft tissues in rat
por: Savisto, Nina, et al.
Publicado: (2023)

[(18)F]CFT synthesis and binding to monoamine transporters in rats
por: Forsback, Sarita, et al.
Publicado: (2012)

[(18)F]SPA-RQ/PET Study of NK1 receptors in the Whole Body of Guinea Pig and Rat
por: Grönroos, Tove J., et al.
Publicado: (2019)

In vivo characterization of a novel norepinephrine transporter PET tracer [(18)F]NS12137 in adult and immature Sprague-Dawley rats
por: López-Picón, Francisco R., et al.
Publicado: (2019)

Intravenous transplantation of olfactory ensheathing cells reduces neuroinflammation after spinal cord injury via interleukin-1 receptor antagonist
por: Zhang, Lijian, et al.
Publicado: (2021)

Uptake of [(18)F] EF5 as a Tracer for Hypoxic and Aggressive Phenotype in Experimental Head and Neck Squamous Cell Carcinoma()
por: Silén, Jonna, et al.
Publicado: (2014)

Comparative Evaluation of Anti-HER2 Affibody Molecules Labeled with (64)Cu Using NOTA and NODAGA
por: Tolmachev, Vladimir, et al.
Publicado: (2017)

Fast growth associated with aberrant vasculature and hypoxia in fibroblast growth factor 8b (FGF8b) over-expressing PC-3 prostate tumour xenografts
por: Tuomela, Johanna, et al.
Publicado: (2010)

Evaluation of repeated [(18)F]EF5 PET/CT scans and tumor growth rate in experimental head and neck carcinomas
por: Silvoniemi, Antti, et al.
Publicado: (2014)

Repeatability of tumour hypoxia imaging using [(18)F]EF5 PET/CT in head and neck cancer
por: Silvoniemi, Antti, et al.
Publicado: (2017)

Effect of genotype and age on cerebral [(18)F]FDG uptake varies between transgenic APP(Swe)-PS1(dE9) and Tg2576 mouse models of Alzheimer’s disease
por: Snellman, Anniina, et al.
Publicado: (2019)

Radiosynthesis and Preclinical Evaluation of [(18)F]F-DPA, A Novel Pyrazolo[1,5a]pyrimidine Acetamide TSPO Radioligand, in Healthy Sprague Dawley Rats
por: Keller, Thomas, et al.
Publicado: (2017)

Vacuum ultraviolet photon–mediated production of [(18)F]F(2)
por: Krzyczmonik, Anna, et al.
Publicado: (2017)

Ruthenium-Mediated (18)F-Fluorination and Preclinical Evaluation of a New CB(1) Receptor Imaging Agent [(18)F]FPATPP
por: Lahdenpohja, Salla, et al.
Publicado: (2020)

Molecular design of radiocopper-labelled Affibody molecules
por: Tolmachev, Vladimir, et al.
Publicado: (2018)

In vivo PET imaging of beta-amyloid deposition in mouse models of Alzheimer's disease with a high specific activity PET imaging agent [(18)F]flutemetamol
por: Snellman, Anniina, et al.
Publicado: (2014)

Increased Brain Fatty Acid Uptake in Metabolic Syndrome
por: Karmi, Anna, et al.
Publicado: (2010)

Two weeks of moderate-intensity continuous training, but not high-intensity interval training, increases insulin-stimulated intestinal glucose uptake
por: Motiani, Kumail K., et al.
Publicado: (2017)

The Anti-Inflammatory Effects of Lipoxygenase and Cyclo-Oxygenase Inhibitors in Inflammation-Induced Human Fetal Glia Cells and the Aβ Degradation Capacity of Human Fetal Astrocytes in an Ex vivo Assay
por: Pihlaja, Rea, et al.
Publicado: (2017)

Direct Comparison of [(18)F]F-DPA with [(18)F]DPA-714 and [(11)C]PBR28 for Neuroinflammation Imaging in the same Alzheimer’s Disease Model Mice and Healthy Controls
por: López-Picón, Francisco R., et al.
Publicado: (2021)

The effects of molar activity on [(18)F]FDOPA uptake in patients with neuroendocrine tumors
por: Stormezand, Gilles N., et al.
Publicado: (2021)

ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer’s disease with a bispecific, brain-penetrating fusion protein
por: Bonvicini, Gillian, et al.
Publicado: (2022)

Optimization of time frame binning for FDOPA uptake quantification in glioma
por: Girard, Antoine, et al.
Publicado: (2020)

In Vivo Availability of Cannabinoid 1 Receptor Levels in Patients With First-Episode Psychosis
por: Borgan, Faith, et al.
Publicado: (2019)

Adrenal tracer uptake by (18)F-FDOPA PET/CT in patients with pheochromocytoma and controls
por: Noordzij, Walter, et al.
Publicado: (2019)

Evaluation of [(18)F]F-DPA PET for Detecting Microglial Activation in the Spinal Cord of a Rat Model of Neuropathic Pain
por: Shimochi, Saeka, et al.
Publicado: (2022)

Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells
por: Pihlaja, Rea, et al.
Publicado: (2015)

Cerebral [(18)F]-FDOPA Uptake in Autism Spectrum Disorder and Its Association with Autistic Traits
por: Schalbroeck, Rik, et al.
Publicado: (2021)

Quantification of [(18)F]DPA-714 binding in the human brain: initial studies in healthy controls and Alzheimer's disease patients
por: Golla, Sandeep S V, et al.
Publicado: (2015)

Hypoxia, blood flow and metabolism in squamous-cell carcinoma of the head and neck: correlations between multiple immunohistochemical parameters and PET
por: Grönroos, Tove J, et al.
Publicado: (2014)

[18F] FDOPA standardized uptake values of brain tumors are not exclusively dependent on LAT1 expression
por: Dadone-Montaudié, Bérengère, et al.
Publicado: (2017)

Changes in electrocardiogram parameters during acute nonshivering cold exposure and associations with brown adipose tissue activity, plasma catecholamine levels, and brachial blood pressure in healthy adults
por: Raiko, Juho R. H., et al.
Publicado: (2021)

Basal and cold-induced fatty acid uptake of human brown adipose tissue is impaired in obesity
por: Saari, T. J., et al.
Publicado: (2020)

Amphetamine Decreases α(2C)-Adrenoceptor Binding of [(11)C]ORM-13070: A PET Study in the Primate Brain
por: Finnema, Sjoerd J, et al.
Publicado: (2015)

MGMT Promoter Methylation and IDH1 Mutations Do Not Affect [(18)F]FDOPA Uptake in Primary Brain Tumors
por: Cimini, Andrea, et al.
Publicado: (2020)

Cessation of anti-VLA-4 therapy in a focal rat model of multiple sclerosis causes an increase in neuroinflammation
por: Vainio, S. K., et al.
Publicado: (2019)

Striatal dopamine synthesis capacity in autism spectrum disorder and its relation with social defeat: an [(18)F]-FDOPA PET/CT study
por: Schalbroeck, Rik, et al.
Publicado: (2021)

The effect of AUT00206, a Kv3 potassium channel modulator, on dopamine synthesis capacity and the reliability of [(18)F]-FDOPA imaging in schizophrenia
por: Angelescu, Ilinca, et al.
Publicado: (2022)

Evaluation of Intraperitoneal [(18)F]-FDOPA Administration for Micro-PET Imaging in Mice and Assessment of the Effect of Subchronic Ketamine Dosing on Dopamine Synthesis Capacity
por: Halff, Els F., et al.
Publicado: (2022)

An automatic analysis framework for FDOPA PET neuroimaging
por: Nordio, Giovanna, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_gmt9d4id57hbbqtuqorneldgrh