Differential regulation of HIF-mediated pathways increases mitochondrial metabolism and ATP production in hypoxic osteoclasts

Inappropriate osteoclast activity instigates pathological bone loss in rheumatoid arthritis. We have investigated how osteoclasts generate sufficient ATP for the energy-intensive process of bone resorption in the hypoxic microenvironment associated with this rheumatic condition. We show that in huma...

Descripción completa

Detalles Bibliográficos
Autores principales: Morten, Karl J, Badder, Luned, Knowles, Helen J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2013
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618370/
https://www.ncbi.nlm.nih.gov/pubmed/23303559
http://dx.doi.org/10.1002/path.4159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618370/
https://www.ncbi.nlm.nih.gov/pubmed/23303559
http://dx.doi.org/10.1002/path.4159

Ejemplares similares