Computational Evolutionary Analysis of the Overlapped Surface (S) and Polymerase (P) Region in Hepatitis B Virus Indicates the Spacer Domain in P Is Crucial for Survival

INTRODUCTION: The Hepatitis B Virus (HBV) genome contains four ORFs, S (surface), P (polymerase), C (core) and X. S is completely overlapped by P and as a consequence the overlapping region is subject to distinctive evolutionary constraints compared to the remainder of the genome. Specifically, a no...

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Detalles Bibliográficos
Autores principales: Chen, Ping, Gan, Yun, Han, Na, Fang, Wei, Li, Jiafu, Zhao, Fei, Hu, Kanghong, Rayner, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618453/
https://www.ncbi.nlm.nih.gov/pubmed/23577084
http://dx.doi.org/10.1371/journal.pone.0060098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618453/
https://www.ncbi.nlm.nih.gov/pubmed/23577084
http://dx.doi.org/10.1371/journal.pone.0060098

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