Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co–therapy

Rifampicin and isoniazid co–therapy frequently causes liver injury in humans. A pregnane X receptor–humanized mouse model revealed that rifampicin and isoniazid co–treatment causes accumulation of protoporphyrin IX, an endogenous hepatotoxin, in the liver via a pregnane X receptor–mediated alteratio...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Feng, Lu, Jie, Cheng, Jie, Wang, Laiyou, Matsubara, Tsutomu, Csanaky, Iván L., Klaassen, Curtis D., Gonzalez, Frank J., Ma, Xiaochao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618537/
https://www.ncbi.nlm.nih.gov/pubmed/23475203
http://dx.doi.org/10.1038/nm.3104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618537/
https://www.ncbi.nlm.nih.gov/pubmed/23475203
http://dx.doi.org/10.1038/nm.3104

Ejemplares similares