A solution to release twisted DNA during chromosome replication by coupled DNA polymerases

Chromosomal replication machines contain coupled DNA polymerases that simultaneously replicate the leading and lagging strands(1). However, coupled replication presents a largely unrecognized topological problem. Since DNA polymerase must travel a helical path during synthesis, the physical connecti...

Descripción completa

Detalles Bibliográficos
Autores principales: Kurth, Isabel, Georgescu, Roxana E., O’Donnell, Mike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618558/
https://www.ncbi.nlm.nih.gov/pubmed/23535600
http://dx.doi.org/10.1038/nature11988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618558/
https://www.ncbi.nlm.nih.gov/pubmed/23535600
http://dx.doi.org/10.1038/nature11988

Ejemplares similares