Structure-Function Analyses of the Human SIX1–EYA2 Complex Reveal Insights into Metastasis and BOR Syndrome

SIX1 interacts with EYA to form a bipartite transcription factor essential for development. Loss of function of this complex causes branchio-oto-renal syndrome (BOR), while re-expression of SIX1 or EYA promotes metastasis. Here we describe the 2.0 Å structure of SIX1 bound to EYA2, which suggests a...

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Detalles Bibliográficos
Autores principales: Patrick, Aaron N, Cabrera, Joshua H, Smith, Anna L, Chen, Xiaojiang S, Ford, Heide L, Zhao, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618615/
https://www.ncbi.nlm.nih.gov/pubmed/23435380
http://dx.doi.org/10.1038/nsmb.2505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618615/
https://www.ncbi.nlm.nih.gov/pubmed/23435380
http://dx.doi.org/10.1038/nsmb.2505

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