Global CNS Gene Delivery and Evasion of Anti-AAV Neutralizing Antibodies by Intrathecal AAV Administration in Non-Human Primates

Injection of AAV into the cerebrospinal fluid (CSF) offers a means to achieve widespread transgene delivery to the central nervous system, where the doses can be readily translated from small to large animals. In contrast to studies with other serotypes (AAV2, AAV4, AAV5) in rodents, we report that...

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Detalles Bibliográficos
Autores principales: Gray, Steven J., Kalburgi, Sahana Nagabhushan, McCown, Thomas J., Samulski, R. Jude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618620/
https://www.ncbi.nlm.nih.gov/pubmed/23303281
http://dx.doi.org/10.1038/gt.2012.101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618620/
https://www.ncbi.nlm.nih.gov/pubmed/23303281
http://dx.doi.org/10.1038/gt.2012.101

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