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Radiation-induced non-targeted response in vivo: role of the TGFβ-TGFBR1-COX-2 signalling pathway

BACKGROUND: Previous studies from our group and others have shown that cyclooxygenase-2 (COX-2) has an essential role in radiation-induced non-targeted responses and genomic instability in vivo. However, the signalling pathways involved in such effects remain unclear. METHODS: A 1 cm(2) area (1 cm ×...

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Detalles Bibliográficos
Autores principales: Chai, Y, Lam, R K K, Calaf, G M, Zhou, H, Amundson, S, Hei, T K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619070/
https://www.ncbi.nlm.nih.gov/pubmed/23412109
http://dx.doi.org/10.1038/bjc.2013.53