Cargando…

Putative tumour suppressor gene necdin is hypermethylated and mutated in human cancer

BACKGROUND: Necdin (NDN) expression is downregulated in telomerase-immortalised normal human urothelial cells. Telomerase-immortalised normal human urothelial cells have no detected genetic alterations. Accordingly, many of the genes whose expression is altered following immortalisation are those fo...

Descripción completa

Detalles Bibliográficos
Autores principales:	De Faveri, L E, Hurst, C D, Platt, F M, Taylor, C F, Roulson, J-A, Sanchez-Carbayo, M, Knowles, M A, Chapman, E J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Genetics & Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619261/ https://www.ncbi.nlm.nih.gov/pubmed/23549060 http://dx.doi.org/10.1038/bjc.2013.104

Ejemplares similares

RASSF2, a potential tumour suppressor, is silenced by CpG island hypermethylation in gastric cancer
por: Endoh, M, et al.
Publicado: (2005)

Promoter hypermethylation of MGMT, CDH1, RAR-β and SYK tumour suppressor genes in granulosa cell tumours (GCTs) of ovarian origin
por: Dhillon, V S, et al.
Publicado: (2004)

Polycomb Repressor Complex 1 Member, BMI1 Contributes to Urothelial Tumorigenesis through p16-Independent Mechanisms()
por: De Faveri, Lia E., et al.
Publicado: (2015)

Identification of Endoglin as an epigenetically regulated tumour-suppressor gene in lung cancer
por: O'Leary, K, et al.
Publicado: (2015)

METH-2 silencing and promoter hypermethylation in NSCLC
por: Dunn, J R, et al.
Publicado: (2004)

Functional epigenomics approach to identify methylated candidate tumour suppressor genes in renal cell carcinoma
por: Morris, M R, et al.
Publicado: (2008)

Fibulin 1 is downregulated through promoter hypermethylation in gastric cancer
por: Cheng, Y Y, et al.
Publicado: (2008)

Mechanisms of inactivation of the tumour suppressor gene RHOA in colorectal cancer
por: Dopeso, Higinio, et al.
Publicado: (2018)

Methylation of tumour suppressor genes APAF-1 and DAPK-1 and in vitro effects of demethylating agents in bladder and kidney cancer
por: Christoph, F, et al.
Publicado: (2006)

Promoter hypermethylation of FANCF and outcome in advanced ovarian cancer
por: Lim, S L, et al.
Publicado: (2008)

Epigenetic deregulation of multiple S100 gene family members by differential hypomethylation and hypermethylation events in medulloblastoma
por: Lindsey, J C, et al.
Publicado: (2007)

Prognostic significance of downregulated expression of the candidate tumour suppressor gene SASH1 in colon cancer
por: Rimkus, C, et al.
Publicado: (2006)

A novel 1p36.2 located gene, APITD1, with tumour-suppressive properties and a putative p53-binding domain, shows low expression in neuroblastoma tumours
por: Krona, C, et al.
Publicado: (2004)

Analysis of human prostate cancers and cell lines for mutations in the TP53 and KLF6 tumour suppressor genes
por: Mühlbauer, K-R, et al.
Publicado: (2003)

Reduced BRCA1 expression due to promoter hypermethylation in therapy-related acute myeloid leukaemia
por: Scardocci, A, et al.
Publicado: (2006)

DNA hypermethylation in the normal colonic mucosa of patients with colorectal cancer
por: Kawakami, K, et al.
Publicado: (2006)

MicroRNA profiling of peripheral nerve sheath tumours identifies miR-29c as a tumour suppressor gene involved in tumour progression
por: Presneau, N, et al.
Publicado: (2013)

Hypermethylation of genes in testicular embryonal carcinomas
por: Cheung, Hoi-Hung, et al.
Publicado: (2016)

Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma
por: Buechner, J, et al.
Publicado: (2011)

DLEC1 is a functional 3p22.3 tumour suppressor silenced by promoter CpG methylation in colon and gastric cancers
por: Ying, J, et al.
Publicado: (2009)

Loss of heterozygosity at 9q33 and hypermethylation of the DBCCR1 gene in oral squamous cell carcinoma
por: Gao, S, et al.
Publicado: (2004)

Putative tumour-suppressor gene DAB2 is frequently down regulated by promoter hypermethylation in nasopharyngeal carcinoma
por: Tong, Joanna H, et al.
Publicado: (2010)

Analysis of the candidate 8p21 tumour suppressor, BNIP3L, in breast and ovarian cancer
por: Lai, J, et al.
Publicado: (2003)

Lymphoid tumours and breast cancer in ataxia telangiectasia; substantial protective effect of residual ATM kinase activity against childhood tumours
por: Reiman, A, et al.
Publicado: (2011)

Necdin is a breast cancer metastasis suppressor that regulates the transcription of c-Myc
por: Lee, Minnkyong, et al.
Publicado: (2015)

Promoter hypermethylation of the Chfr gene in neoplastic and non-neoplastic gastric epithelia
por: Honda, T, et al.
Publicado: (2004)

Analysis of molecular intra-patient variation and delineation of a prognostic 12-gene signature in non-muscle invasive bladder cancer; technology transfer from microarrays to PCR
por: Dyrskjøt, L, et al.
Publicado: (2012)

Relevance of BCAR4 in tamoxifen resistance and tumour aggressiveness of human breast cancer
por: Godinho, M F E, et al.
Publicado: (2010)

Tumour suppressors miR-1 and miR-133a target the oncogenic function of purine nucleoside phosphorylase (PNP) in prostate cancer
por: Kojima, S, et al.
Publicado: (2012)

Intra-tumour genetic heterogeneity and poor chemoradiotherapy response in cervical cancer
por: Cooke, S L, et al.
Publicado: (2011)

11q13 amplification status and human papillomavirus in relation to p16 expression defines two distinct etiologies of head and neck tumours
por: Ragin, C C R, et al.
Publicado: (2006)

A novel germline mutation of PTEN associated with brain tumours of multiple lineages
por: Staal, F J T, et al.
Publicado: (2002)

Common genetic variants in the 9p21 region and their associations with multiple tumours
por: Gu, F, et al.
Publicado: (2013)

RASSF1A hypermethylation in pretreatment serum DNA of neuroblastoma patients: a prognostic marker
por: Misawa, A, et al.
Publicado: (2009)

Gene expression profiling of noninvasive primary urothelial tumours using microarrays
por: Aaboe, M, et al.
Publicado: (2005)

Frequent downregulation of 14-3-3 σ protein and hypermethylation of 14-3-3 σ gene in salivary gland adenoid cystic carcinoma
por: Uchida, D, et al.
Publicado: (2004)

Long-term survival and transmission of INI1-mutation via nonpenetrant males in a family with rhabdoid tumour predisposition syndrome
por: Ammerlaan, A C J, et al.
Publicado: (2008)

Sequence variation of necdin gene in Bovidae
por: Peters, Sunday O., et al.
Publicado: (2018)

Tasman-PCR: a genetic diagnostic assay for Tasmanian devil facial tumour diseases
por: Kwon, Young Mi, et al.
Publicado: (2018)

Lack of mutations within ST7 gene in tumour-derived cell lines and primary epithelial tumours
por: Brown, V L, et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_oi8q5a3lmv3erd18aca5rsmlru