Identification of human-selective analogues of the vascular-disrupting agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)

BACKGROUND: Species selectivity of DMXAA (5,6-dimethylxanthenone-4-acetic acid, Vadimezan) for murine cells over human cells could explain in part the recent disappointing phase III trials clinical results when preclinical studies were so promising. To identify analogues with greater human clinical...

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Detalles Bibliográficos
Autores principales: Tijono, S M, Guo, K, Henare, K, Palmer, B D, Wang, L-C S, Albelda, S M, Ching, L-M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619269/
https://www.ncbi.nlm.nih.gov/pubmed/23481185
http://dx.doi.org/10.1038/bjc.2013.101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619269/
https://www.ncbi.nlm.nih.gov/pubmed/23481185
http://dx.doi.org/10.1038/bjc.2013.101

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