Design of Thymidine Analogues Targeting Thymidilate Kinase of Mycobacterium tuberculosis

We design here new nanomolar antituberculotics, inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase (TMPKmt), by means of structure-based molecular design. 3D models of TMPKmt-inhibitor complexes have been prepared from the crystal structure of TMPKmt cocrystallized with the natu...

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Detalles Bibliográficos
Autores principales: Owono Owono, Luc Calvin, Keita, Melalie, Megnassan, Eugene, Frecer, Vladimir, Miertus, Stanislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619541/
https://www.ncbi.nlm.nih.gov/pubmed/23634301
http://dx.doi.org/10.1155/2013/670836

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619541/
https://www.ncbi.nlm.nih.gov/pubmed/23634301
http://dx.doi.org/10.1155/2013/670836

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