Vitamin K Antagonist Warfarin for Palliative Treatment of Metachromatic Leukodystrophy, A Compassionate Study of Four Subjects

MLD is characterized by accumulation of sulfatides in the brain. Vitamin K regulates two enzymes in sphingolipid biosynthesis and warfarin is known to lower brain sulfatides in rats and mice. We hypothesized that warfarin may mitigate the MLD phenotype by reducing the formation of sulfatides. This c...

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Detalles Bibliográficos
Autores principales: Assadi, Mitra, Wang, Dah-Jyuu, Anderson, Kelly, Carran, Melissa, Bilaniuk, Larissa, Leone, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619661/
https://www.ncbi.nlm.nih.gov/pubmed/23650469
http://dx.doi.org/10.4137/JCNSD.S9355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619661/
https://www.ncbi.nlm.nih.gov/pubmed/23650469
http://dx.doi.org/10.4137/JCNSD.S9355

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