Development of a Medium-term Animal Model Using gpt Delta Rats to Evaluate Chemical Carcinogenicity and Genotoxicity

In this study, the potential for development of an animal model (GPG46) capable of rapidly detecting chemical carcinogenicity and the underlying mechanisms of action were examined in gpt delta rats using a reporter gene assay to detect mutations and a medium-term rat liver bioassay to detect tumor p...

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Detalles Bibliográficos
Autores principales: Matsushita, Kohei, Kijima, Aki, Ishii, Yuji, Takasu, Shinji, Jin, Meilan, Kuroda, Ken, Kawaguchi, Hiroaki, Miyoshi, Noriaki, Nohmi, Takehiko, Ogawa, Kumiko, Umemura, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Toxicologic Pathology 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620210/
https://www.ncbi.nlm.nih.gov/pubmed/23723564
http://dx.doi.org/10.1293/tox.26.19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620210/
https://www.ncbi.nlm.nih.gov/pubmed/23723564
http://dx.doi.org/10.1293/tox.26.19

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