Cargando…

Development of a Medium-term Animal Model Using gpt Delta Rats to Evaluate Chemical Carcinogenicity and Genotoxicity

In this study, the potential for development of an animal model (GPG46) capable of rapidly detecting chemical carcinogenicity and the underlying mechanisms of action were examined in gpt delta rats using a reporter gene assay to detect mutations and a medium-term rat liver bioassay to detect tumor p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Matsushita, Kohei, Kijima, Aki, Ishii, Yuji, Takasu, Shinji, Jin, Meilan, Kuroda, Ken, Kawaguchi, Hiroaki, Miyoshi, Noriaki, Nohmi, Takehiko, Ogawa, Kumiko, Umemura, Takashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Japanese Society of Toxicologic Pathology 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620210/ https://www.ncbi.nlm.nih.gov/pubmed/23723564 http://dx.doi.org/10.1293/tox.26.19

Ejemplares similares

Background data of 2-year-old male and female F344 gpt delta rats
por: Matsushita, Kohei, et al.
Publicado: (2020)

Role of oxidative stress in the chemical structure-related genotoxicity of nitrofurantoin in Nrf2-deficient gpt delta mice
por: Tsuchiya, Takuma, et al.
Publicado: (2018)

Thresholds of Genotoxic and Non-Genotoxic Carcinogens
por: Nohmi, Takehiko
Publicado: (2018)

Mutagenicity of carcinogenic heterocyclic amines in Salmonella typhimurium YG strains and transgenic rodents including gpt delta
por: Nohmi, Takehiko, et al.
Publicado: (2021)

Validation study of the combined repeated-dose toxicity and genotoxicity assay using gpt delta rats
por: Akagi, Jun-ichi, et al.
Publicado: (2015)

Genotoxic responses to titanium dioxide nanoparticles and fullerene in gpt delta transgenic MEF cells
por: Xu, An, et al.
Publicado: (2009)

Integration of In Vivo Genotoxicity and Short-term Carcinogenicity Assays Using F344 gpt Delta Transgenic Rats: In Vivo Mutagenicity of 2,4-Diaminotoluene and 2,6-Diaminotoluene Structural Isomers
por: Toyoda-Hokaiwado, Naomi, et al.
Publicado: (2010)

Genomic integration of lambda EG10 transgene in gpt delta transgenic rodents
por: Masumura, Kenichi, et al.
Publicado: (2015)

Effects of the scid mutation on X-ray-induced deletions in the brain and spleen of gpt delta mice
por: Masumura, Kenichi, et al.
Publicado: (2020)

Characteristic mutations induced in the small intestine of Msh2-knockout gpt delta mice
por: Aoki, Yasunobu, et al.
Publicado: (2021)

New Insight into Intrachromosomal Deletions Induced by Chrysotile in the gpt delta Transgenic Mutation Assay
por: Xu, An, et al.
Publicado: (2007)

Estimation of the frequency of inherited germline mutations by whole exome sequencing in ethyl nitrosourea-treated and untreated gpt delta mice
por: Masumura, Kenichi, et al.
Publicado: (2016)

New homozygous gpt delta transgenic rat strain improves an efficiency of the in vivo mutagenicity assay
por: Masumura, Kenichi, et al.
Publicado: (2021)

Alterations in the mutagenicity and mutation spectrum induced by benzo[a]pyrene instilled in the lungs of gpt delta mice of various ages
por: Aoki, Yasunobu, et al.
Publicado: (2015)

Effects of Nrf2 silencing on oxidative stress‐associated intestinal carcinogenesis in mice
por: Yokoo, Yuh, et al.
Publicado: (2016)

Change over time of the mutagenicity in the lungs of gpt delta transgenic mice by extract of airborne particles collected from ambient air in the Tokyo metropolitan area
por: Aoki, Yasunobu, et al.
Publicado: (2018)

Genotoxicity assessment of titanium dioxide nanoparticle accumulation of 90 days in the liver of gpt delta transgenic mice
por: Suzuki, Tetsuya, et al.
Publicado: (2020)

Mechanisms of oxidative stress-induced in vivo mutagenicity by potassium bromate and nitrofurantoin
por: Tsuchiya, Takuma, et al.
Publicado: (2018)

Correction to: Genotoxicity assessment of titanium dioxide nanoparticle accumulation of 90 days in the liver of gpt delta transgenic mice
por: Suzuki, Tetsuya, et al.
Publicado: (2020)

Are genotoxic carcinogens more potent than nongenotoxic carcinogens?
por: Parodi, S, et al.
Publicado: (1991)

Radiation induced COX-2 expression and mutagenesis at non-targeted lung tissues of gpt delta transgenic mice
por: Chai, Y, et al.
Publicado: (2013)

Quantitative Approaches to Assess Key Carcinogenic Events of Genotoxic Carcinogens
por: Fukushima, Shoji, et al.
Publicado: (2018)

Mequindox Induced Genotoxicity and Carcinogenicity in Mice
por: Liu, Qianying, et al.
Publicado: (2018)

Thirdhand smoke: Genotoxicity and carcinogenic potential
por: Hang, Bo, et al.
Publicado: (2019)

A novel, integrated in vitro carcinogenicity test to identify genotoxic and non-genotoxic carcinogens using human lymphoblastoid cells
por: Wilde, Eleanor C., et al.
Publicado: (2017)

Databases of genotoxicity and carcinogenicity and their usefulness for hazard evaluation.
Publicado: (1991)

Corrigendum: Mequindox Induced Genotoxicity and Carcinogenicity in Mice
por: Liu, Qianying, et al.
Publicado: (2018)

Comparison of Reversibility of Rat Forestomach Lesions Induced by Genotoxic and Non‐genotoxic Carcinogens
por: Kagawa, Masataka, et al.
Publicado: (1993)

Investigating the Different Mechanisms of Genotoxic and Non-Genotoxic Carcinogens by a Gene Set Analysis
por: Lee, Won Jun, et al.
Publicado: (2014)

Anomalous nonidentity between Salmonella genotoxicants and rodent carcinogens: nongenotoxic carcinogens and genotoxic noncarcinogens.
por: Yoshikawa, K
Publicado: (1996)

Short-term in vivo testing to discriminate genotoxic carcinogens from non-genotoxic carcinogens and non-carcinogens using next-generation RNA sequencing, DNA microarray, and qPCR
por: Furihata, Chie, et al.
Publicado: (2023)

Data selection and treatment of chemicals tested for genotoxicity and carcinogenicity.
por: Loprieno, N, et al.
Publicado: (1991)

A Mode-of-Action Approach for the Identification of Genotoxic Carcinogens
por: Hernández, Lya G., et al.
Publicado: (2013)

Genotoxicity and carcinogenicity of cobalt-, nickel- and copper-based nanoparticles
por: MAGAYE, RUTH, et al.
Publicado: (2012)

Mode of action-based risk assessment of genotoxic carcinogens
por: Hartwig, Andrea, et al.
Publicado: (2020)

Threshold of Toxicological Concern—An Update for Non-Genotoxic Carcinogens
por: Batke, Monika, et al.
Publicado: (2021)

Effect of sampling time on somatic and germ cell mutations induced by acrylamide in gpt delta mice
por: Hagio, Soichiro, et al.
Publicado: (2021)

Role of genotoxic and nongenotoxic effects in multistage carcinogenicity of aromatic amines.
por: Neumann, H G, et al.
Publicado: (1990)

Analysis and comparison of information and data recorded in carcinogenicity and genotoxicity databases.
por: Romano, P, et al.
Publicado: (1991)

Mathematical models for exploring different aspects of genotoxicity and carcinogenicity databases.
por: Benigni, R, et al.
Publicado: (1991)

Cannot write session to /tmp/vufind_sessions/sess_j9ffg68iost82r1n53dhru11ag