Cargando…

An Integrated Approach to Uncover Driver Genes in Breast Cancer Methylation Genomes

BACKGROUND: Cancer cells typically exhibit large-scale aberrant methylation of gene promoters. Some of the genes with promoter methylation alterations play “driver” roles in tumorigenesis, whereas others are only “passengers”. RESULTS: Based on the assumption that promoter methylation alteration of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shen, Xiaopei, Li, Shan, Zhang, Lin, Li, Hongdong, Hong, Guini, Zhou, XianXiao, Zheng, Tingting, Zhang, Wenjing, Hao, Chunxiang, Shi, Tongwei, Liu, Chunyang, Guo, Zheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620319/ https://www.ncbi.nlm.nih.gov/pubmed/23579546 http://dx.doi.org/10.1371/journal.pone.0061214

Ejemplares similares

Genes Dysregulated to Different Extent or Oppositely in Estrogen Receptor-Positive and Estrogen Receptor-Negative Breast Cancers
por: Zhou, Xianxiao, et al.
Publicado: (2013)

Similar Source of Differential Blood mRNAs in Lung Cancer and Pulmonary Inflammatory Diseases: Calls for Improved Strategy for Identifying Cancer-Specific Biomarkers
por: Hong, Guini, et al.
Publicado: (2014)

Reproducibility and Concordance of Differential DNA Methylation and Gene Expression in Cancer
por: Yao, Chen, et al.
Publicado: (2012)

Common DNA methylation alterations of Alzheimer's disease and aging in peripheral whole blood
por: Li, Hongdong, et al.
Publicado: (2016)

Editorial: Novel approaches and concepts of biomarker discovery for cancer
por: Hong, Guini, et al.
Publicado: (2022)

Identifying disease-associated pathways in one-phenotype data based on reversal gene expression orderings
por: Hong, Guini, et al.
Publicado: (2017)

Uncovering Driver DNA Methylation Events in Nonsmoking Early Stage Lung Adenocarcinoma
por: Zhang, Xindong, et al.
Publicado: (2016)

Distinct Functional Patterns of Gene Promoter Hypomethylation and Hypermethylation in Cancer Genomes
por: Shen, Xiaopei, et al.
Publicado: (2012)

Multidimensional integrative analysis uncovers driver candidates and biomarkers in penile carcinoma
por: Marchi, Fabio Albuquerque, et al.
Publicado: (2017)

Identifying Reproducible Molecular Biomarkers for Gastric Cancer Metastasis with the Aid of Recurrence Information
por: Li, Mengyao, et al.
Publicado: (2016)

Identification of molecular alterations in leukocytes from gene expression profiles of peripheral whole blood of Alzheimer’s disease
por: Li, Hongdong, et al.
Publicado: (2017)

Identifying primary site of lung-limited Cancer of unknown primary based on relative gene expression orderings
por: Li, Mengyao, et al.
Publicado: (2019)

An exposomic framework to uncover environmental drivers of aging
por: Kalia, Vrinda, et al.
Publicado: (2022)

Differential expression analysis for individual cancer samples based on robust within-sample relative gene expression orderings across multiple profiling platforms
por: Guan, Qingzhou, et al.
Publicado: (2016)

DriverNet: uncovering the impact of somatic driver mutations on transcriptional networks in cancer
por: Bashashati, Ali, et al.
Publicado: (2012)

An individualized prognostic signature for gastric cancer patients treated with 5-Fluorouracil-based chemotherapy and distinct multi-omics characteristics of prognostic groups
por: Li, Xiangyu, et al.
Publicado: (2016)

Identification of an Individualized Prognostic Biomarker for Serous Ovarian Cancer: A Qualitative Model
por: Luo, Fengyuan, et al.
Publicado: (2022)

An integrated computational and experimental study uncovers FUT9 as a metabolic driver of colorectal cancer
por: Auslander, Noam, et al.
Publicado: (2017)

Uncovering potential genes in colorectal cancer based on integrated and DNA methylation analysis in the gene expression omnibus database
por: Wang, Guanglin, et al.
Publicado: (2022)

Screening prognostic markers for hepatocellular carcinoma based on pyroptosis-related lncRNA pairs
por: Wu, Tong, et al.
Publicado: (2023)

Identifying CpG sites with different differential methylation frequencies in colorectal cancer tissues based on individualized differential methylation analysis
por: Yan, Haidan, et al.
Publicado: (2017)

PertInInt: An Integrative, Analytical Approach to Rapidly Uncover Cancer Driver Genes with Perturbed Interactions and Functionalities
por: Kobren, Shilpa Nadimpalli, et al.
Publicado: (2020)

Genome‐wide screening of abberant methylated drivers combined with relative risk loci in bladder cancer
por: Zhang, Chuanjie, et al.
Publicado: (2019)

Integrating Mendelian randomization and multiple-trait colocalization to uncover cell-specific inflammatory drivers of autoimmune and atopic disease
por: McGowan, Lucy M, et al.
Publicado: (2019)

Construct of qualitative diagnostic biomarkers specific for glioma by pairing serum microRNAs
por: Li, Hongdong, et al.
Publicado: (2023)

Hiding in the dark: uncovering cancer drivers through image-guided genomics
por: Yoshihara, Kosuke, et al.
Publicado: (2014)

Uncovering drivers of dose-dependence and individual variation in malaria infection outcomes
por: Kamiya, Tsukushi, et al.
Publicado: (2020)

Genome-wide mapping of somatic mutation rates uncovers drivers of cancer
por: Sherman, Maxwell A., et al.
Publicado: (2022)

Integrating Multi-Omics for Uncovering the Architecture of Cross-Talking Pathways in Breast Cancer
por: Wang, Li, et al.
Publicado: (2014)

Predict ovarian cancer by pairing serum miRNAs: Construct of single sample classifiers
por: Hong, Guini, et al.
Publicado: (2022)

Sex specific molecular networks and key drivers of Alzheimer’s disease
por: Guo, Lei, et al.
Publicado: (2023)

Correction: Integrating Multi-Omics for Uncovering the Architecture of Cross-Talking Pathways in Breast Cancer
por: Wang, Li, et al.
Publicado: (2019)

Hospital Trusts productivity in the English NHS: Uncovering possible drivers of productivity variations
por: Aragon Aragon, María Jose, et al.
Publicado: (2017)

Landscape of transcriptome variations uncovering known and novel driver events in colorectal carcinoma
por: Pira, Giovanna, et al.
Publicado: (2020)

Integration of Genome-Wide DNA Methylation and Transcription Uncovered Aberrant Methylation-Regulated Genes and Pathways in the Peripheral Blood Mononuclear Cells of Systemic Sclerosis
por: Zhu, Honglin, et al.
Publicado: (2018)

Effects of automation trust in drivers’ visual distraction during automation
por: Zhang, Yijing, et al.
Publicado: (2021)

Uncovering the Subtype-Specific Molecular Characteristics of Breast Cancer by Multiomics Analysis of Prognosis-Associated Genes, Driver Genes, Signaling Pathways, and Immune Activity
por: Li, Xinhui, et al.
Publicado: (2021)

An Integrative Pharmacology-Based Pattern to Uncover the Pharmacological Mechanism of Ginsenoside H Dripping Pills in the Treatment of Depression
por: Zhao, Libin, et al.
Publicado: (2021)

Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes
por: Koedoot, Esmee, et al.
Publicado: (2019)

An integrated epigenomic-transcriptomic landscape of lung cancer reveals novel methylation driver genes of diagnostic and therapeutic relevance
por: Sun, Xiwei, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_0ddltgbcct95t0s7e2ctvqhc97