Cargando…
PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis
Immune responses to persistent viral infections and cancer often fail because of intense regulation of antigen-specific T cells—a process referred to as immune exhaustion. The mechanisms that underlie the induction of exhaustion are not completely understood. To gain novel insights into this process...
Autores principales: | Zinselmeyer, Bernd H., Heydari, Sara, Sacristán, Catarina, Nayak, Debasis, Cammer, Michael, Herz, Jasmin, Cheng, Xiaoxiao, Davis, Simon J., Dustin, Michael L., McGavern, Dorian B. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620347/ https://www.ncbi.nlm.nih.gov/pubmed/23530125 http://dx.doi.org/10.1084/jem.20121416 |
Ejemplares similares
-
Development of an Immunologically Tolerated Combination of Fluorescent Proteins for In vivo Two-photon Imaging
por: Gossa, Selamawit, et al.
Publicado: (2014) -
Type I Interferon Programs Innate Myeloid Dynamics and Gene Expression in the Virally Infected Nervous System
por: Nayak, Debasis, et al.
Publicado: (2013) -
Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells
por: Herz, Jasmin, et al.
Publicado: (2015) -
Migration of cytotoxic lymphocytes in cell cycle permits local MHC I–dependent control of division at sites of viral infection
por: Kang, Silvia S., et al.
Publicado: (2011) -
BST-2 controls T cell proliferation and exhaustion by shaping the early distribution of a persistent viral infection
por: Urata, Shuzo, et al.
Publicado: (2018)