Epithelial and dendritic cells in the thymic medulla promote CD4(+)Foxp3(+) regulatory T cell development via the CD27–CD70 pathway

CD4(+)Foxp3(+) regulatory T cells (T(reg) cells) are largely autoreactive yet escape clonal deletion in the thymus. We demonstrate here that CD27–CD70 co-stimulation in the thymus rescues developing T(reg) cells from apoptosis and thereby promotes T(reg) cell generation. Genetic ablation of CD27 or...

Descripción completa

Detalles Bibliográficos
Autores principales: Coquet, Jonathan M., Ribot, Julie C., Bąbała, Nikolina, Middendorp, Sabine, van der Horst, Gerda, Xiao, Yanling, Neves, Joana F., Fonseca-Pereira, Diogo, Jacobs, Heinz, Pennington, Daniel J., Silva-Santos, Bruno, Borst, Jannie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620350/
https://www.ncbi.nlm.nih.gov/pubmed/23547099
http://dx.doi.org/10.1084/jem.20112061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620350/
https://www.ncbi.nlm.nih.gov/pubmed/23547099
http://dx.doi.org/10.1084/jem.20112061

Ejemplares similares