Cargando…

Epithelial and dendritic cells in the thymic medulla promote CD4(+)Foxp3(+) regulatory T cell development via the CD27–CD70 pathway

CD4(+)Foxp3(+) regulatory T cells (T(reg) cells) are largely autoreactive yet escape clonal deletion in the thymus. We demonstrate here that CD27–CD70 co-stimulation in the thymus rescues developing T(reg) cells from apoptosis and thereby promotes T(reg) cell generation. Genetic ablation of CD27 or...

Descripción completa

Detalles Bibliográficos
Autores principales:	Coquet, Jonathan M., Ribot, Julie C., Bąbała, Nikolina, Middendorp, Sabine, van der Horst, Gerda, Xiao, Yanling, Neves, Joana F., Fonseca-Pereira, Diogo, Jacobs, Heinz, Pennington, Daniel J., Silva-Santos, Bruno, Borst, Jannie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620350/ https://www.ncbi.nlm.nih.gov/pubmed/23547099 http://dx.doi.org/10.1084/jem.20112061

Ejemplares similares

The thymic medulla is required for Foxp3(+) regulatory but not conventional CD4(+) thymocyte development
por: Cowan, Jennifer E., et al.
Publicado: (2013)

CD27 Promotes Survival of Activated T Cells and Complements CD28 in Generation and Establishment of the Effector T Cell Pool
por: Hendriks, Jenny, et al.
Publicado: (2003)

CD4(+) T cell help creates memory CD8(+) T cells with innate and help-independent recall capacities
por: Ahrends, Tomasz, et al.
Publicado: (2019)

Antigen Recognition By Autoreactive Cd4(+) Thymocytes Drives Homeostasis Of The Thymic Medulla
por: Irla, Magali, et al.
Publicado: (2012)

Depletion of CD8+ cells in human thymic medulla results in selective immune deficiency
Publicado: (1989)

The CD70-CD27 axis in oncology: the new kids on the block
por: Flieswasser, Tal, et al.
Publicado: (2022)

Interrogating the CD27:CD70 axis in αCD40-dependent control of pancreatic adenocarcinoma
por: Gamache, Awndre, et al.
Publicado: (2023)

Coexpression of CD25 and CD27 identifies FoxP3(+) regulatory T cells in inflamed synovia
por: Ruprecht, Claudia R., et al.
Publicado: (2005)

Clinical Significance of BTLA, CD27, CD70, CD28 and CD80 as Diagnostic and Prognostic Markers in Ovarian Cancer
por: Świderska, Janina, et al.
Publicado: (2022)

c-Rel is required for the development of thymic Foxp3(+) CD4 regulatory T cells
por: Isomura, Iwao, et al.
Publicado: (2010)

c-Rel is required for the development of thymic Foxp3(+) CD4 regulatory T cells
por: Isomura, Iwao, et al.
Publicado: (2009)

HSP70 Enhances Immunosuppressive Function of CD4(+)CD25(+)FoxP3(+) T Regulatory Cells and Cytotoxicity in CD4(+)CD25(−) T Cells
por: Wachstein, Julian, et al.
Publicado: (2012)

Direct Detection of FoxP3 Expression in Thymic Double-Negative CD4(−)CD8(−) Cells by Flow Cytometry
por: Liu, Gang, et al.
Publicado: (2014)

The price of the CD27–CD70 costimulatory axis: you can't have it all
por: Nolte, Martijn A., et al.
Publicado: (2006)

Structural delineation and phase-dependent activation of the costimulatory CD27:CD70 complex
por: Liu, Weifeng, et al.
Publicado: (2021)

Inherited CD70 deficiency in humans reveals a critical role for the CD70–CD27 pathway in immunity to Epstein-Barr virus infection
por: Izawa, Kazushi, et al.
Publicado: (2017)

Antigen-Specificity in the Thymic Development and Peripheral Activity of CD4(+)FOXP3(+) T Regulatory Cells
por: Pohar, Jelka, et al.
Publicado: (2018)

RANK signals from CD4(+)3(−) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla
por: Rossi, Simona W., et al.
Publicado: (2007)

Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs
por: Bowakim-Anta, Natalia, et al.
Publicado: (2023)

CD70 in Thymic Squamous Cell Carcinoma: Potential Diagnostic Markers and Immunotherapeutic Targets
por: Kashima, Jumpei, et al.
Publicado: (2022)

Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20(+)CD27(+)CD43(+)CD70(−)
por: Griffin, Daniel O., et al.
Publicado: (2011)

Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20(+)CD27(+)CD43(+)CD70(−)
por: Griffin, Daniel O., et al.
Publicado: (2011)

Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20(+)CD27(+)CD43(+)CD70(−)
por: Griffin, Daniel O., et al.
Publicado: (2011)

Gene Expression of CD70 and CD27 Is Increased in Alopecia Areata Lesions and Associated with Disease Severity and Activity
por: Sayed Mahmoud Marie, Radwa El-, et al.
Publicado: (2022)

c-Rel Controls Multiple Discrete Steps in the Thymic Development of Foxp3(+) CD4 Regulatory T Cells
por: Grigoriadis, George, et al.
Publicado: (2011)

Androgen receptor modulates Foxp3 expression in CD4(+)CD25(+)Foxp3(+) regulatory T-cells
por: Walecki, Magdalena, et al.
Publicado: (2015)

CD70–CD27 ligation between neural stem cells and CD4(+) T cells induces Fas–FasL-mediated T-cell death
por: Lee, Eun Mi, et al.
Publicado: (2013)

CD70/CD27 signaling promotes blast stemness and is a viable therapeutic target in acute myeloid leukemia
por: Riether, Carsten, et al.
Publicado: (2017)

Clinical Significance of Down-Regulated CD70 and CD27 Expression in Poor Prognosis of Esophageal Squamous Cell Carcinoma
por: Shan, Ting-ting, et al.
Publicado: (2020)

Targeting the CD27-CD70 Pathway to Improve Outcomes in Both Checkpoint Immunotherapy and Allogeneic Hematopoietic Cell Transplantation
por: Lutfi, Forat, et al.
Publicado: (2021)

Nasopharyngeal carcinoma cells promote regulatory T cell development and suppressive activity via CD70-CD27 interaction
por: Gong, Lanqi, et al.
Publicado: (2023)

P802: CD70/CD27 SIGNALING PROMOTES THE EXPANSION OF CLONAL PLASMA CELL SUBSETS IN MULTIPLE MYELOMA
por: Forster, Stefan, et al.
Publicado: (2023)

The novel high-affinity humanized antibody IMM40H targets CD70, eliminates tumors via Fc-mediated effector functions, and interrupts CD70/CD27 signaling
por: Li, Song, et al.
Publicado: (2023)

The control of CD4(+)CD25(+)Foxp3(+ )regulatory T cell survival
por: Pandiyan, Pushpa, et al.
Publicado: (2008)

Identity of mysterious CD4(+)CD25(-)Foxp3(+ )cells in SLE
por: Horwitz, David A
Publicado: (2010)

Helpless Priming Sends CD8(+) T Cells on the Road to Exhaustion
por: Busselaar, Julia, et al.
Publicado: (2020)

Blockade of TGF-β signaling to enhance the antitumor response is accompanied by dysregulation of the functional activity of CD4(+)CD25(+)Foxp3(+) and CD4(+)CD25(−)Foxp3(+) T cells
por: Polanczyk, Magdalena J., et al.
Publicado: (2019)

Thymic DCs derived IL-27 regulates the final maturation of CD4(+) SP thymocytes
por: Tang, Hui, et al.
Publicado: (2016)

Two subsets of epithelial cells in the thymic medulla
Publicado: (1992)

Numerical status of CD4(+)CD25(+)FoxP3(+) and CD8(+)CD28(-) regulatory T cells in multiple sclerosis
por: Kouchaki, Ebrahim, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_c3jm4rmhch6o7vqtev5mh7vee9