RhoGEF12 controls cardiac remodeling by integrating G protein– and integrin-dependent signaling cascades

Structural cardiac remodeling, including hypertrophy and fibrosis, plays a crucial role in the pathogenesis of heart failure. In vitro studies suggested a role of the small GTPase RhoA in hypertrophic cardiomyocyte growth, but neither the molecular mechanisms leading to RhoA activation nor their rel...

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Detalles Bibliográficos
Autores principales: Takefuji, Mikito, Krüger, Marcus, Sivaraj, Kishor K., Kaibuchi, Kozo, Offermanns, Stefan, Wettschureck, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620351/
https://www.ncbi.nlm.nih.gov/pubmed/23530122
http://dx.doi.org/10.1084/jem.20122126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620351/
https://www.ncbi.nlm.nih.gov/pubmed/23530122
http://dx.doi.org/10.1084/jem.20122126

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