Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin

4-1BB agonist antibody treatment induces a population of KLRG1(+) T cells that infiltrate melanoma tumors. We investigated the origin and function of these cells, as well as their place within established T cell paradigms. We find that these T cells, particularly the CD4 lineage, represent a novel p...

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Detalles Bibliográficos
Autores principales: Curran, Michael A., Geiger, Theresa L., Montalvo, Welby, Kim, Myoungjoo, Reiner, Steven L., Al-Shamkhani, Aymen, Sun, Joseph C., Allison, James P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620352/
https://www.ncbi.nlm.nih.gov/pubmed/23547098
http://dx.doi.org/10.1084/jem.20121190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620352/
https://www.ncbi.nlm.nih.gov/pubmed/23547098
http://dx.doi.org/10.1084/jem.20121190

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