Specific Notch receptor–ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength

In humans, high Notch activation promotes γδ T cell development, whereas lower levels promote αβ-lineage differentiation. How these different Notch signals are generated has remained unclear. We show that differential Notch receptor–ligand interactions mediate this process. Whereas Delta-like 4 supp...

Descripción completa

Detalles Bibliográficos
Autores principales: Van de Walle, Inge, Waegemans, Els, De Medts, Jelle, De Smet, Greet, De Smedt, Magda, Snauwaert, Sylvia, Vandekerckhove, Bart, Kerre, Tessa, Leclercq, Georges, Plum, Jean, Gridley, Thomas, Wang, Tao, Koch, Ute, Radtke, Freddy, Taghon, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620353/
https://www.ncbi.nlm.nih.gov/pubmed/23530123
http://dx.doi.org/10.1084/jem.20121798

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620353/
https://www.ncbi.nlm.nih.gov/pubmed/23530123
http://dx.doi.org/10.1084/jem.20121798

Ejemplares similares