Identification of Anziaic Acid, a Lichen Depside from Hypotrachyna sp., as a New Topoisomerase Poison Inhibitor

Topoisomerase inhibitors are effective for antibacterial and anticancer therapy because they can lead to the accumulation of the intermediate DNA cleavage complex formed by the topoisomerase enzymes, which trigger cell death. Here we report the application of a novel enzyme-based high-throughput scr...

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Detalles Bibliográficos
Autores principales: Cheng, Bokun, Cao, Shugeng, Vasquez, Victor, Annamalai, Thirunavukkarasu, Tamayo-Castillo, Giselle, Clardy, Jon, Tse-Dinh, Yuk-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620467/
https://www.ncbi.nlm.nih.gov/pubmed/23593306
http://dx.doi.org/10.1371/journal.pone.0060770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620467/
https://www.ncbi.nlm.nih.gov/pubmed/23593306
http://dx.doi.org/10.1371/journal.pone.0060770

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