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Crystal Structure of Human Aurora B in Complex with INCENP and VX-680
[Image: see text] We present the structure of the human Aurora B kinase domain in complex with the C-terminal Aurora-binding region of human INCENP and the Aurora kinase inhibitor VX-680. The structure unexpectedly reveals a dimeric arrangement of the Aurora B:INCENP complex, which was confirmed to...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621106/ https://www.ncbi.nlm.nih.gov/pubmed/22920039 http://dx.doi.org/10.1021/jm3008954 |