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Crystal Structure of Human Aurora B in Complex with INCENP and VX-680

[Image: see text] We present the structure of the human Aurora B kinase domain in complex with the C-terminal Aurora-binding region of human INCENP and the Aurora kinase inhibitor VX-680. The structure unexpectedly reveals a dimeric arrangement of the Aurora B:INCENP complex, which was confirmed to...

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Detalles Bibliográficos
Autores principales:	Elkins, Jonathan M., Santaguida, Stefano, Musacchio, Andrea, Knapp, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2012
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621106/ https://www.ncbi.nlm.nih.gov/pubmed/22920039 http://dx.doi.org/10.1021/jm3008954

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