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Dual effects of daily FTY720 on human astrocytes in vitro: relevance for neuroinflammation
BACKGROUND: FTY720 (fingolimod, Gilenya™) is a daily oral therapy for multiple sclerosis that readily accesses the central nervous system (CNS). FTY720 is a structural analog to the sphingolipid sphingosine-1-phosphate (S1P) and is a cognate ligand for the S1P G-protein coupled receptors (S1PR). Stu...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621211/ https://www.ncbi.nlm.nih.gov/pubmed/23509960 http://dx.doi.org/10.1186/1742-2094-10-41 |