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Effects of Δ40p53, an isoform of p53 lacking the N-terminus, on transactivation capacity of the tumor suppressor protein p53

BACKGROUND: The p53 protein is expressed as multiple isoforms that differ in their N- and C-terminus due to alternative splicing, promoter or codon initiation usage. Δ40p53 lacks the first 39 residues containing the main transcriptional activation domain, resulting from initiation of translation at...

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Detalles Bibliográficos
Autores principales: Hafsi, Hind, Santos-Silva, Daniela, Courtois-Cox, Stéphanie, Hainaut, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621643/
https://www.ncbi.nlm.nih.gov/pubmed/23514281
http://dx.doi.org/10.1186/1471-2407-13-134