Reduction of the Cholesterol Sensor SCAP in the Brains of Mice Causes Impaired Synaptic Transmission and Altered Cognitive Function

The sterol sensor SCAP is a key regulator of SREBP-2, the major transcription factor controlling cholesterol synthesis. Recently, we showed that there is a global down-regulation of cholesterol synthetic genes, as well as SREBP-2, in the brains of diabetic mice, leading to a reduction of cholesterol...

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Detalles Bibliográficos
Autores principales: Suzuki, Ryo, Ferris, Heather A., Chee, Melissa J., Maratos-Flier, Eleftheria, Kahn, C. Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621654/
https://www.ncbi.nlm.nih.gov/pubmed/23585733
http://dx.doi.org/10.1371/journal.pbio.1001532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621654/
https://www.ncbi.nlm.nih.gov/pubmed/23585733
http://dx.doi.org/10.1371/journal.pbio.1001532

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