Cargando…

Betaine supplement alleviates hepatic triglyceride accumulation of apolipoprotein E deficient mice via reducing methylation of peroxisomal proliferator-activated receptor alpha promoter

BACKGROUND: Betaine is a methyl donor and has been considered as a lipotropic effect substance. But its mechanism remains unclear. Hepatic steatosis is associated with abnormal expression of genes involved in hepatic lipid metabolism. DNA methylation contributes to the disregulation of gene expressi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Lijun, Chen, Li, Tan, Yaozong, Wei, Jun, Chang, Ying, Jin, Tianru, Zhu, Huilian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621752/ https://www.ncbi.nlm.nih.gov/pubmed/23497035 http://dx.doi.org/10.1186/1476-511X-12-34

Ejemplares similares

Betaine Supplementation Attenuates S-Adenosylhomocysteine Hydrolase-Deficiency-Accelerated Atherosclerosis in Apolipoprotein E-Deficient Mice
por: Dai, Xin, et al.
Publicado: (2022)

Alleviation of Carbon-Tetrachloride-Induced Liver Injury and Fibrosis by Betaine Supplementation in Chickens
por: Tsai, Meng-Tsz, et al.
Publicado: (2015)

Metabolome Analysis Reveals Betaine Lipids as Major Source for Triglyceride Formation, and the Accumulation of Sedoheptulose during Nitrogen-Starvation of Phaeodactylum tricornutum
por: Popko, Jennifer, et al.
Publicado: (2016)

Maternal Betaine Supplementation Mitigates Maternal High Fat Diet-Induced NAFLD in Offspring Mice through Gut Microbiota
por: Sun, Liuqiao, et al.
Publicado: (2023)

Peroxisome Proliferator-Activated Receptor Alpha Target Genes
por: Rakhshandehroo, Maryam, et al.
Publicado: (2010)

Impaired T cell-mediated hepatitis in peroxisome proliferator activated receptor alpha (PPARα)-deficient mice
por: Hines, Ian N., et al.
Publicado: (2018)

Effects of Cariprazine, Aripiprazole, and Olanzapine on Mouse Fibroblast Culture: Changes in Adiponectin Contents in Supernatants, Triglyceride Accumulation, and Peroxisome Proliferator-Activated Receptor-γ Expression
por: Bába, László-István, et al.
Publicado: (2019)

Adaptation of peroxisome proliferator-activated receptor alpha to hibernation in bats
por: Han, Yijie, et al.
Publicado: (2015)

Effect of betaine supplementation on power performance and fatigue
por: Hoffman, Jay R, et al.
Publicado: (2009)

Effect of betaine supplementation on cycling sprint performance
por: Pryor, J Luke, et al.
Publicado: (2012)

8-Hydroxyeicosapentaenoic Acid Decreases Plasma and Hepatic Triglycerides via Activation of Peroxisome Proliferator-Activated Receptor Alpha in High-Fat Diet-Induced Obese Mice
por: Yamada, Hidetoshi, et al.
Publicado: (2016)

Magnolol Alleviates Inflammatory Responses and Lipid Accumulation by AMP-Activated Protein Kinase-Dependent Peroxisome Proliferator-Activated Receptor α Activation
por: Tian, Ye, et al.
Publicado: (2018)

Betaine Alleviates Hypertriglycemia and Tau Hyperphosphorylation in db/db Mice
por: Jung, Ga-young, et al.
Publicado: (2013)

Apolipoprotein E synthesized by adipocyte and apolipoprotein E carried on lipoproteins modulate adipocyte triglyceride content
por: Li, Yan-hong, et al.
Publicado: (2014)

Ergogenic effects of betaine supplementation on strength and power performance
por: Lee, Elaine C, et al.
Publicado: (2010)

Effects of phosphatidylcholine and betaine supplements on women's serum choline
por: Hoffman, M. Camille, et al.
Publicado: (2019)

Mechanisms Involved in the Enhanced Susceptibility of Senescent Rats to the Hepatocarcinogenic Effect of Peroxisome Proliferators: Role of Peroxisome Proliferator-Activated Receptor alpha (PPAR), Cell Proliferation and Oxidative Stress
por: Youssef, Jihan A., et al.
Publicado: (2001)

Tumorigenicity of the hypolipidaemic peroxisome proliferator ethyl-alpha-p-chlorophenoxyisobutyrate (clofibrate) in rats.
por: Reddy, J. K., et al.
Publicado: (1979)

Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha
por: Li, Guolin, et al.
Publicado: (2017)

Hepatic Peroxisome Proliferator-Activated Receptor Alpha Dysfunction in Porcine Septic Shock
por: Vandewalle, Jolien, et al.
Publicado: (2022)

Mechanistic insights into the peroxisome proliferator-activated receptor alpha as a transcriptional suppressor
por: Yagai, Tomoki, et al.
Publicado: (2022)

Peroxisome biogenesis and human peroxisome-deficiency disorders
por: FUJIKI, Yukio
Publicado: (2016)

Hepatic Lipid Accumulation Alters Global Histone H3 Lysine 9 and 4 Trimethylation in the Peroxisome Proliferator-Activated Receptor Alpha Network
por: Jun, Hee-Jin, et al.
Publicado: (2012)

Genetic variants in Apolipoprotein AV alter triglyceride concentrations in pregnancy
por: Ward, Kirsten J, et al.
Publicado: (2003)

Apolipoprotein A5 regulates intracellular triglyceride metabolism in adipocytes
por: Zheng, Xiao-Yan, et al.
Publicado: (2017)

Alpha‐lipoic acid alleviates NAFLD and triglyceride accumulation in liver via modulating hepatic NLRP3 inflammasome activation pathway in type 2 diabetic rats
por: Ko, Chih‐Yuan, et al.
Publicado: (2021)

Glycine Betaine Accumulation, Significance and Interests for Heavy Metal Tolerance in Plants
por: Ali, Shafaqat, et al.
Publicado: (2020)

Hepatocellular proliferation in response to agonists of peroxisome proliferator-activated receptor alpha: a role for kupffer cells?
por: Alsarra, Ibrahim A, et al.
Publicado: (2006)

The Metabolic Burden of Methyl Donor Deficiency with Focus on the Betaine Homocysteine Methyltransferase Pathway
por: Obeid, Rima
Publicado: (2013)

Effects of supplemental betaine to semen extenders on semen quality in boars
por: Lugar, D W, et al.
Publicado: (2018)

Ablation of Tumor Necrosis Factor Alpha Receptor 1 Signaling Blunts Steatohepatitis in Peroxisome Proliferator Activated Receptor α-Deficient Mice
por: Hines, Ian N., et al.
Publicado: (2022)

Correction: Hepatic Lipid Accumulation Alters Global Histone H3 Lysine 9 and 4 Trimethylation in the Peroxisome Proliferator-Activated Receptor Alpha Network
por: Jun, Hee-Jin, et al.
Publicado: (2012)

Inhalation exposure to 2-ethyl-1-hexanol causes hepatomegaly and transient lipid accumulation without induction of peroxisome proliferator-activated receptor alpha in mice
por: WAKAYAMA, Takanari, et al.
Publicado: (2021)

Peroxisome Proliferators: Response
por: Melnick, R
Publicado: (2001)

Perplexing peroxisome proliferators.
por: Citron, M
Publicado: (1995)

Developmental Effects of Perfluorononanoic Acid in the Mouse Are Dependent on Peroxisome Proliferator-Activated Receptor-Alpha
por: Wolf, Cynthia J., et al.
Publicado: (2010)

Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol induced steatohepatitis in mice
por: Kong, Lingbo, et al.
Publicado: (2011)

Activation and Expression of Peroxisome Proliferator-Activated Receptor Alpha Are Associated with Tumorigenesis in Colorectal Carcinoma
por: Morinishi, Tatsuya, et al.
Publicado: (2019)

Peroxisome Proliferator-Activated Receptor Alpha Mediates the Beneficial Effects of Atorvastatin in Experimental Colitis
por: Basso, Paulo José, et al.
Publicado: (2021)

Exploring compounds to be used as cosmetic agents that activate peroxisome proliferator‐activated receptor alpha
por: Tachibana, Keisuke, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1o9in0p09gad6do61tfqaq4iiq