Metabolism and Pharmacokinetics of the Anti-Tuberculosis Drug Ethionamide in a Flavin-Containing Monooxygenase Null Mouse

Multiple drug resistance (MDR) in Mycobacterium tuberculosis (mTB), the causative agent for tuberculosis (TB), has led to increased use of second-line drugs, including ethionamide (ETA). ETA is a prodrug bioactivated by mycobacterial and mammalian flavin-containing monooxygenases (FMOs). FMO2 is the...

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Detalles Bibliográficos
Autores principales: Palmer, Amy L., Leykam, Virginia L., Larkin, Andrew, Krueger, Sharon K., Phillips, Ian R., Shephard, Elizabeth A., Williams, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621790/
https://www.ncbi.nlm.nih.gov/pubmed/23580869
http://dx.doi.org/10.3390/ph5111147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621790/
https://www.ncbi.nlm.nih.gov/pubmed/23580869
http://dx.doi.org/10.3390/ph5111147

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