CD19 CAR-Targeted T Cells Induce Long-Term Remission and B Cell Aplasia in an Immunocompetent Mouse Model of B Cell Acute Lymphoblastic Leukemia

Although many adults with B cell acute lymphoblastic leukemia (B-ALL) are induced into remission, most will relapse, underscoring the dire need for novel therapies for this disease. We developed murine CD19-specific chimeric antigen receptors (CARs) and an immunocompetent mouse model of B-ALL that r...

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Detalles Bibliográficos
Autores principales: Davila, Marco L., Kloss, Christopher C., Gunset, Gertrude, Sadelain, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621858/
https://www.ncbi.nlm.nih.gov/pubmed/23585892
http://dx.doi.org/10.1371/journal.pone.0061338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621858/
https://www.ncbi.nlm.nih.gov/pubmed/23585892
http://dx.doi.org/10.1371/journal.pone.0061338

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