Re-Directing an Alkylating Agent to Mitochondria Alters Drug Target and Cell Death Mechanism

We have successfully delivered a reactive alkylating agent, chlorambucil (Cbl), to the mitochondria of mammalian cells. Here, we characterize the mechanism of cell death for mitochondria-targeted chlorambucil (mt-Cbl) in vitro and assess its efficacy in a xenograft mouse model of leukemia. Using a ρ...

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Detalles Bibliográficos
Autores principales: Mourtada, Rida, Fonseca, Sonali B., Wisnovsky, Simon P., Pereira, Mark P., Wang, Xiaoming, Hurren, Rose, Parfitt, Jeremy, Larsen, Lesley, Smith, Robin A. J., Murphy, Michael P., Schimmer, Aaron D., Kelley, Shana O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621862/
https://www.ncbi.nlm.nih.gov/pubmed/23585833
http://dx.doi.org/10.1371/journal.pone.0060253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621862/
https://www.ncbi.nlm.nih.gov/pubmed/23585833
http://dx.doi.org/10.1371/journal.pone.0060253

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